International Neurotoxicology Association (INA-18) Meeting in Durham, NC, USA
Click here for Full Digital Schedule May 21 – May 25, 2023
Conference Overview:
Sunday, May 21
9:45-10:00: Welcoming Remarks: Tim Shafer, INA President
10:00-12:00: Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology
Co-Chairs: Jason Cannon, Purdue University and Jonathan Doorn, University of Iowa
Neuromelanin-neurotoxicant interactions underlie selective dopaminergic neuron sensitivity
Jason Cannon, Purdue University
Neurotoxicant-mediated catecholaminergic stress: reactive intermediates and biomarkers
Jonathan Doorn, University of Iowa
Redox signaling involved in the regulation of the neurotoxic interaction between α-synuclein and environmental toxicants
Rodrigo Franco, University of Nebraska-Lincoln
Hyperactivation of the DNA damage response underlies vulnerability of dopaminergic neurons in LRRK2- related Parkinson’s disease
Laurie Sanders, Duke University
12:00-1:00: Lunch
1:00-3:30: The Landscape for Regulatory Neurotoxicity in the Future
Co-Chairs: Tim Shafer, US-EPA and Laura Carlson, US-EPA
International efforts in optimizing developmental neurotoxicity testing for regulatory applications
Tim Shafer, US-EPA
Key Characteristics for Neurotoxicity and their application to Decision Making/Use of New Approach Methods from a State Health Agency
Pam Lein and Lauren Zeise, University of California-Davis and California-EPA
Using an Integrated Approach to Testing and Assessment to Evaluate in vitro Positives in the OECD Developmental Neurotoxicity Screening Battery
Sue Marty, Dow Chemical Company
US EPA’s Use of NAMs for Regulatory Purposes
Anna Lowitt, US-EPA
The European landscape for the incorporation of NAMs in the chemical risk assessment
Iris Mangas, EFSA
3:30-3:45: Afternoon Break
3:45-5:15: Trainee Talks
Neurotoxicity of non-volatile and semi-volatile diesel exhaust-derived ultrafine particles
Lora-Sophie Gerber, Utrecht University
Autistic-like behavior and immune dysfunction in rats early-exposed to alpha-hexabromo-cyclododecane: A potential contributor to the emergence of autism spectrum disorders
Chloe Morel, Université de Lorraine
Slc39a14 knockout mice: A genetic model of manganese-induced dystonia parkinsonism exhibits neurodegenerative changes in the cerebellum and brainstem
Alexander Rodichkin, Florida International University
6:00-9:00: Welcoming Dinner
Hoosima Lecture
Dopamine in Durham: location, location, location
Gary Miller, Columbia University
Monday, May 22
8:30-10:30: Bridging Across Experimental Model Systems to Advance Neurotoxicology Screening with Meaning Well into the 21st Century
Co-Chairs: Edward D. Levin, Duke University and Remco Westerink, Utrecht University
Bridging inter- and intraspecies differences in vitro to facilitate screening in neurotoxicology
Emma E.J. Kasteel, Laura Hondebrink, Anke Tukker, and Remco H.S. Westerink,Utrecht University and Purdue University
Bridging between in vitro models and animal studies: behavioral phenotyping in the invertebrate planarian Dugesia japonica
Eva-Maria S. Collins, Swarthmore College
Expanding the zebrafish neurobehavioral screening toolbox to more rapidly detect neurobehavioral toxicants across life stage
Robyn L. Tanguay, Oregon State University
Bridging analyses of neurobehavioral toxicity between zebrafish and rats
Andrew B. Hawkey and Edward D. Levin, Midwestern University and Duke University
10:30-10:45: Morning Break
10:45-12:15: Peripheral Neurotoxicity
Chair: Christoph van Thriel, Leibniz Research Centre for Working Environment and Human Factors
Mechanisms of chronic toxicity in the vestibular sensory epithelium
Jordi Llorens, Universitat de Barcelona
Using long-term cultures of DRG neurons to identify mechanisms of peripheral neurotoxicity of gadolinium-based contrast agents (GBCAs)
Christoph van Thriel, Leibniz Research Centre for Working Environment and Human Factors
Genetic susceptibility to optic nerve demyelination during lead toxicity.
Patrick Kerstein, Purdue University
12:15-1:15: Lunch
1:15-3:15: Mapping Effects of Early Life Exposure In Vitro
Co-Chairs: Ellen Hessell, National Institute for Public Health and the Environment (RIVM) and Anke Tukker, Purdue University
The human neural progenitor cell test (hNPT) as a model for compound-induced developmental
Neurotoxicity
Victoria de Leeuw, National Institute for Public Health and the Environment (RIVM)
Early life exposure to MeHg causes persistent effect in hiPSC-derived cortical neurons:
Developmental exposure to MeHg results in a persistently altered homeostatic state in human iPSC-derived cortical glutamatergic cultures
Anke Tukker, Purdue University,
The added value of nematodes to fill the gaps in developmental neurotoxicity Adverse Outcome
Pathways
Samantha Hughes, Vrije Universiteit Amsterdam
The development of a standardized assay for testing the potential neurotoxicity of compounds using zebrafish embryo/larval assays
Lee Ellis, National Research Council of Canada
3:15-3:30: Afternoon Break
3:30-5:00: Open Platform Talks
Neurobehavioral effects of prenatal and perinatal PFAS exposure through drinking water
Liping Feng, Duke University
A novel zebrafish-based high-throughput platform for modeling neurological disorders and performing drug screenings in F0
Vincenzo Di Donato, Institut Germans Trias i Pujol, Badalona
Effects of eating food containing red meat on inflammation in adult risks: A risk of neurotoxicity for the brain?
Henri Schroeder, Université de Lorraine
6:00-8:00: Poster Session (see list below)
Buffet Dinner
Tuesday, May 23
8:30-10:30: Neurological Effects of SARS-CoV-2
Chair: Helena Hogberg, National Institute of Environmental Health Sciences
A Systematic Evidence Map of Neurological Effects due to COVID-19
Helena Hogberg, National Institute of Environmental Health Sciences (NIEHS),
The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19
Magda Sachana, Organisation for Economic Co-operation and Development (OECD)
Systems Biology Approaches to COVID-19 Pathogenesis
Daniel Jacobson, Biosciences Division, Oak Ridge National Laboratory
Multiscale Approaches to Elucidate Interactions in Neurological Outcomes of COVID-19
Ann Lam, Physicians Committee for Responsible Medicine
10:30-10:45: Morning Break
10:45-11:45: Pioneer in Neurotoxicology Lecture
Organophosphate insecticides in retrospect: Lessons learned when a “safe” pesticide isn’t safe
Theodore Slotkin, Duke University
11:45-12:45: Open Platform Talks
Structure-based chemical clustering for developmental neurotoxicity and comparison with MEA datasets from iPSC-neurons
Yasunari Kanda, University of Shizuoka
Application of machine learning to neurotoxicity assessment using human iPS cell-derived neurons
Yuta Suzuki, Yokohama National University
12:45-1:45: Lunch
2:30-5:30: Networking Activities
- A) Nasher Art Museum
- B) Duke Chapel and History of Medicine Library
- C) Duke Homestead
All) Sarah Duke Botanical Gardens
6:00-7:00: Soccer Match at Durham Central Park
7:00-9:00: Carolina Barbeque Dinner and Bluegrass Music at Durham Central Park
Wednesday, May 24
8:30-11:00: Linking Endocrine Signaling to Developmental Neurotoxicity (DNT) to Establish Novel Methods for Endocrine Disruption-induced DNT – Results from the ENDpoiNTs Project
Chair: Joëlle Rüegg, Uppsala University
Application of a human in vitro testing battery for endocrine disruptor (ED)-induced developmental neurotoxicity (DNT) to refine EDC hazard assessment
Katharina Koch, Kevin Schlüppmann, Louisa Merit Stark, Saskia Hüsken, Stefan Masjosthusmann, Arif Dönmez, Nils Förster, Ellen Fritsche, Leibniz Research Institute for Environmental Medicine, Ruhr-University Bochum and Heinrich-Heine-University
From Experimental neurobiology to policy making: Unravelling the molecular mechanisms of Endocrine Disruption in the developing human brain
Marco Tullio Rigoli, Cristina Cheroni, Caporale Nicolò, Davide Castaldi, Martina Ciprietti, Sebastiano Trattaro and Giuseppe Testa, European Institute of Oncology, IRCCS, University of Milan and Human Technopole
Sex-specific effects of acute and developmental exposure to bisphenol-A and endosulfan
Lennart V.J. van Melis, Anneloes M. Peerdeman, Eva H.W. Huiberts, Regina G.D.M van Kleef and Remco H.S Westerink, Utrecht University
Cellular and behavioral impacts of EDC on oligodendrogenesis and remyelination
- Jubin, C. Guittoneau, E. Martin, M-S. Aigrot, B. Demeneix, JB. Fini, B. Zalc, S. Remaud, Muséum National d’Histoire Naturelle (MNHN) and Sorbonne University
Adverse Outcome Pathways for Endocrine-induced Developmental Neurotoxicity
Diana Lupu and Joëlle Rüegg, Uppsala University
11:00-11:15: Morning Break
11:15-12:15: Open Platform Talks
The role of brain iron in neurodegenerative diseases
Byron Jones, University of Tennessee Health Science Center
Neuronal genes in wiring and firing: A bottom-up approach for the characterization of gene expression biomarkers for developmental neurotoxicity hazard identification
Bhaja Padhi, Health Canada
12:15-1:15: Lunch
1:15-3:15: Acrylamide as a Neurodevelopmental Toxicant – Linking Molecular and Cellular Mechanisms to Human Behavioral Dysfunction
Co-Chairs: Oddvar Myhre, Norwegian Institute of Public Health and Ylva Johansson, Stockholm University
Effects of acrylamide and its metabolite glycidamide in human neural stem cells undergoing differentiation.
Oddvar Myhre, Malene Lislien, Marcin W. Wojewodzic, Nur Duale, Jørn A. Holme, Ragnhild E Paulsen, Inger Margit Alm, Ellen Skarpen, Vigdis Sørensen, Francesca Pistollato and Anna J Lauvås, Norwegian Institute of Public Health (NIPH), Oslo University Hospital, University of Oslo and 4European Commission, Joint Research Centre (JRC)
Neural differentiation pathway disturbances and neurodevelopmental toxicity of acrylamide in the human neural progenitor test (hNPT).
Victoria C. de Leeuw, Conny T.M. van Oostrom, Paul F.K. Wackers, Jeroen L.A. Pennings, Hennie M. Hodemaekers, Aldert H. Piersma and Ellen V.S. Hessel, National Institute for Public Health and the Environment (RIVM)
Acrylamide impairs neuronal differentiation in neuroblast and neural progenitor cell models at concentrations that are relevant for human exposure
Ylva Johansson, Kristina Attoff, Anna Forsby, Stockholm University and Swedish Chemicals Agency (KEMI)
Neurodevelopmental and other developmental effects of acrylamide in birth cohorts
Jan Alexander, Ida Caspersen, Margaretha Haugen, Oddvar Myhre and Kristine Vejrup, Norwegian Institute of Public Health
3:15-3:30: Afternoon Break
3:30-5:00: New Insights on the Role of Manganese in Neurodegeneration
Co-Chairs: Aaron Bowman, Purdue University and Marcia Ratner, Boston University
BTBD9 is regulated by manganese and attenuates manganese-induced oxidative stress and dopaminergic neurotoxicity
Pan Chen, Aaron B Bowman, and Michael Aschner, Albert Einstein College of Medicine and Purdue University
Neurotoxicological outcomes of sub-cytotoxic manganese exposure and neurodegenerative disease risk
Xueqi Tang, Hyunjin Kim, Anke Tukker, Emily Warren, Miles Bryan, Rekha Balachandran, Fiona Harrison, Michael Aschner and Aaron B. Bowman, Purdue University, Vanderbilt University Medical Center, and Albert Einstein College of Medicine
Manganese exposure as a disease modifying risk factor in age at onset of Parkinson’s disease
Marcia Ratner, Boston University School of Medicine
5:00-6:30: INA Business Meeting and Awards
Dinner on your own
Thursday, May 25
8:30-10:30: Evaluating new approach methodologies for developmental neurotoxicity: computational models to mechanisms of toxicity
Co-Chairs: Kelly Carstens, US-EPA and Megan Culbreth, PETA Science Consortium International
Comparing the strengths and limitations of concentration-response modeling pipelines for developmental neurotoxicity (DNT) new approach methods (NAMs)
Kelly Carstens, US-EPA
Exploring the influence of experimental design on toxicity outcomes in zebrafish embryo tests
Jui-Hua Hsieh, National Institute of Environmental Health Sciences
Building predictive flame retardants models using the multi-dimensional embryonic zebrafish.
Lisa Truong, University of Oregon
Gaining confidence in the developmental neurotoxicity (DNT) in vitro battery by understanding the mechanism of action of screening data
Ellen Fritsche, Leibniz Research Institute for Environmental Medicine
10:30-10:45: Morning Break
10:45-12:15: Translational Neurotoxicology from In silico/In vitro/In vivo Models to Lead Compounds in Chemical Threats Research
Chair: David Jett, National Institute of Neurological Disorders and Stroke
Determination of the Toxicokinetics of TETS and development of neutralizing antibody reagents
Heike Wulff, Brandon Pressly, Natalia Vasylieva, Bogdan Barnych, Vikrant Singh, Pamela J. Lein, Bruce D. Hammock, University of California, Davis
Efficacy testing and pharmacokinetic analysis of novel brain-penetrating oxime acetylcholinesterase reactivators
Janice E. Chambers, Mississippi State University
Refined uncharged bis-oximes for rapid CNS reactivation of OP-inhibited human acetylcholinesterase.
Andrey Kovalevsky, Thibault Alle, Carlo Ballatore and Zoran Radic, Oak Ridge National Laboratory and University of California San Diego
12:15-12:30: Closing Remarks: Tim Shafer, INA President and Pam Lein, INA President-Elect
92 Scientific Presentations at INA18
2 Keynote Lectures
43 Talks in 11 symposia
3 Trainee talks
7 Open Platform Talks
37 Posters (10 Student, 11 Post-doc, 16 Non-trainee)
Posters
| Name | Title of Presentation | Category |
| 1 MaryAnn Hawks | Reductions in neocortical parvalbumin expression due to iodine deficiency and ammonium perchlorate exposure | Student |
| 2 Alan Kim | Synaptogenesis assay for developmental neurotoxicity testing in a human 3D brain model | Student |
| 3 Bridget Knapp | Identifying negative control chemicals for use in larval zebrafish behavior assays | Student |
| 4 Christine Lee Li Mei | Embryonic exposure to neonicotinoid insecticide on neuron-glia interaction in the cerebellum of neonatal rat | Student |
| 5 Daniel Martinez | Translocator Protein 18 kDa (TSPO) and neuroinflammation in the 5XFAD animal model of Alzheimer’s disease | Student |
| 6 Katherine Morton | High sugar diets modulate oxidative stress induction by 6-OHDA to reduce dopaminergic neurodegeneration in C. elegans | Student |
| 7 Sydney Risen | Non-toxic nanoligomers targeting key neuroinflammatory pathways are protective in neurodegenerative disease | Student |
| 8 Diego Ruiz-Sobremazas | Investigating the effects of gestational particulate matter exposure on offspring development and social behavior in rats | Student |
| 9 Xueqi Tang | IGF/Insulin signaling interruption in acute vs. chronic manganese exposure | Student |
| 10 Ryne Thomas | Prevalence of periventricular heterotopia following developmental exposure to perchlorate and dietary iodine deficiency in rats | Student |
| 11 Gimena Gomez | Addressing the impact of PFAS on neurodevelopment using human cortical organoids | Postdoc |
| 12 Javier Huayta | Neurodegeneration induced by inhibition of mitochondrial complex III in Caenorhabditis elegans | Postdoc |
| 13 Dalisa Kendricks | Using automated home-cage behavior monitoring systems to characterize sex differences in mice exposed to chlorpyrifos during gestation | Postdoc |
| 14 Anna Kreutz | Human embryonic stem cell-derived dopaminergic neuron model for neurodevelopmental toxicology screening | Postdoc |
| 15 Rebecca Lichtler | Prenatal cadmium exposure upregulates re5noic acid signaling and posterior Hoxa and Hoxb paralogs in the developing mouse brain | Postdoc |
| 16 Beatriz Molina-Martinez | Neurotoxicity profiling in zebrafish larvae using a battery of high content locomotor activity assays | Postdoc |
| 17 Andrew Newell | Organophophate esters exposure during development dysregulates genes underlying mitochondrial physiology in brain and placenta | Postdoc |
| 18 Emily Pitzer | Developmental emamectin benzoate exposure alters ontological proteomic signatures in Long Evans rats | Postdoc |
| 19 Maren Schenke | Implementing sex differences in an in vitro model of the developing human brain | Postdoc |
| 20 Jack Thornton | Comparative neurotoxicity of traditional and designer benzodiazepines on in vitro spontaneously active rat primary cortical cultures: implications for public health regulation | Postdoc |
| 21 Xian Wu | Tiered testing of arsenic developmental neurotoxicity using neural organoid and 2D in vitro models | Postdoc |
| 22 Gabrielle Bryd | Increasing the throughput of a high-content imaging-based developmental neurotoxicity proliferation assay | Non-trainee |
| 23 Nathalie Grova | Development of an adverse outcome pathway (AOP) to assess the neurotoxicity of the exposure to benzo(a)pyrene | Non-trainee |
| 24 G. Jean Harry | Consideration of microglia as a target neural cell for assessing neurotoxicity. Why is the smallest always overlooked or misunderstood | Non-trainee |
| 25 Bridgett Hill | Inconsistencies in variable reporting and methods in larval zebrafish behavioral assays | Non-trainee |
| 26 Alex Marshall | The influence of arsenic on mechanisms of alcohol-induced neurodegeneration | Non-trainee |
| 27 Christopher McPherson | Integrating screening level developmental neurotoxicity (DNT) information of chemicals In a new approach methods (NAMs) battery to prioritize compounds for future In-depth study | Non-trainee |
| 28 Beatriz Molina-Martinez | Neurotoxicity profiling in zebrafish larvae using a battery of high content locomotor activity assays | Non-trainee |
| 29 Valentina Schiavone | Harmonizing embryonic zebrafish Light/Dark Behavior Test for the OECD Developmental NeuroToxicity In Vitro Battery (OECD DNT IVB) | Non-trainee |
| 30 Lena Smirnova | Organoid Intelligence (OI). Can we replace learning and memory animal studies with in vitro models? | Non-trainee |
| 31 Jacob Smoot | Plastic dominates developmental toxicity responses to burn pit-related smoke in zebrafish: Role for polycyclic aromatic hydrocarbons | Non-trainee |
| 32 Zhi-Bin Tong | 3D-suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons | Non-trainee |
| 33 Remco Westerink | Micro- and nanoplastics neurotoxicity measured using microelectrode array (MEA) recordings in rat cortical cultures | Non-trainee |
| 34 John Wise | Using a toxic aging coin for Cr(VI) neurotoxicity: Investigating the intersection of aging and toxicology of hexavalent chromium in the brain | Non-trainee |
| 35 Sachiko Yoshida | Mutuality between neuronal toxicity and microbiome alteration in acute or chronic exposure to glyphosate | Non-trainee |
| 36 Marie-Gabrielle Zurich | Are glycol ethers neurotoxic for humans? An in vitro and in silico evaluation | Non-trainee |
| 37 Katie Zychowski | Neuroinflammatory, sex-dependent consequences and mechanisms following acute woodsmoke exposure | Non-trainee |