INA-18 Schedule

International Neurotoxicology Association (INA-18) Meeting in Durham, NC, USA

Click here for Full Digital Schedule May 21 – May 25, 2023

Conference Overview:


Sunday, May 21


9:45-10:00:    Welcoming Remarks: Tim Shafer, INA President


10:00-12:00: Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology                                                                                  

Co-Chairs: Jason Cannon, Purdue University and Jonathan Doorn, University of Iowa


Neuromelanin-neurotoxicant interactions underlie selective dopaminergic neuron sensitivity

Jason Cannon, Purdue University


Neurotoxicant-mediated catecholaminergic stress: reactive intermediates and biomarkers

Jonathan Doorn, University of Iowa


Redox signaling involved in the regulation of the neurotoxic interaction between α-synuclein and environmental toxicants

Rodrigo Franco, University of Nebraska-Lincoln


Hyperactivation of the DNA damage response underlies vulnerability of dopaminergic neurons in LRRK2- related Parkinson’s disease

Laurie Sanders, Duke University


12:00-1:00:    Lunch


1:00-3:30:      The Landscape for Regulatory Neurotoxicity in the Future                                

Co-Chairs: Tim Shafer, US-EPA and Laura Carlson, US-EPA


International efforts in optimizing developmental neurotoxicity testing for regulatory applications

Tim Shafer, US-EPA


Key Characteristics for Neurotoxicity and their application to Decision Making/Use of New Approach Methods from a State Health Agency

Pam Lein and Lauren Zeise, University of California-Davis and California-EPA


Using an Integrated Approach to Testing and Assessment to Evaluate in vitro Positives in the OECD Developmental Neurotoxicity Screening Battery

Sue Marty, Dow Chemical Company


US EPA’s Use of NAMs for Regulatory Purposes

Anna Lowitt, US-EPA


The European landscape for the incorporation of NAMs in the chemical risk assessment

Iris Mangas, EFSA


3:30-3:45:      Afternoon Break


3:45-5:15:      Trainee Talks


Neurotoxicity of non-volatile and semi-volatile diesel exhaust-derived ultrafine particles

Lora-Sophie Gerber, Utrecht University


Autistic-like behavior and immune dysfunction in rats early-exposed to alpha-hexabromo-cyclododecane: A potential contributor to the emergence of autism spectrum disorders

Chloe Morel, Université de Lorraine


Slc39a14 knockout mice: A genetic model of manganese-induced dystonia parkinsonism exhibits neurodegenerative changes in the cerebellum and brainstem

Alexander Rodichkin, Florida International University


6:00-9:00:      Welcoming Dinner

Hoosima Lecture

Dopamine in Durham: location, location, location

Gary Miller, Columbia University



Monday, May 22


8:30-10:30:    Bridging Across Experimental Model Systems to Advance Neurotoxicology Screening with Meaning Well into the 21st Century                                               

Co-Chairs: Edward D. Levin, Duke University and Remco Westerink, Utrecht University


Bridging inter- and intraspecies differences in vitro to facilitate screening in neurotoxicology

Emma E.J. Kasteel, Laura Hondebrink, Anke Tukker, and Remco H.S. Westerink,Utrecht University and Purdue University


Bridging between in vitro models and animal studies: behavioral phenotyping in the invertebrate planarian Dugesia japonica

Eva-Maria S. Collins, Swarthmore College


Expanding the zebrafish neurobehavioral screening toolbox to more rapidly detect neurobehavioral toxicants across life stage

Robyn L. Tanguay, Oregon State University


Bridging analyses of neurobehavioral toxicity between zebrafish and rats

Andrew B. Hawkey and Edward D. Levin, Midwestern University and Duke University


10:30-10:45:  Morning Break


10:45-12:15: Peripheral Neurotoxicity

Chair: Christoph van Thriel, Leibniz Research Centre for Working Environment and Human Factors


Mechanisms of chronic toxicity in the vestibular sensory epithelium

Jordi Llorens, Universitat de Barcelona


Using long-term cultures of DRG neurons to identify mechanisms of peripheral neurotoxicity of gadolinium-based contrast agents (GBCAs)

Christoph van Thriel, Leibniz Research Centre for Working Environment and Human Factors


Genetic susceptibility to optic nerve demyelination during lead toxicity.

Patrick Kerstein, Purdue University


12:15-1:15:    Lunch


1:15-3:15:      Mapping Effects of Early Life Exposure In Vitro                                       

Co-Chairs: Ellen Hessell, National Institute for Public Health and the Environment (RIVM) and Anke Tukker, Purdue University


The human neural progenitor cell test (hNPT) as a model for compound-induced developmental


Victoria de Leeuw, National Institute for Public Health and the Environment (RIVM)


Early life exposure to MeHg causes persistent effect in hiPSC-derived cortical neurons:

Developmental exposure to MeHg results in a persistently altered homeostatic state in human iPSC-derived cortical glutamatergic cultures

Anke Tukker, Purdue University,


The added value of nematodes to fill the gaps in developmental neurotoxicity Adverse Outcome


Samantha Hughes, Vrije Universiteit Amsterdam


The development of a standardized assay for testing the potential neurotoxicity of compounds using zebrafish embryo/larval assays

Lee Ellis, National Research Council of Canada


3:15-3:30:      Afternoon Break


3:30-5:00:      Open Platform Talks


Neurobehavioral effects of prenatal and perinatal PFAS exposure through drinking water

Liping Feng, Duke University


A novel zebrafish-based high-throughput platform for modeling neurological disorders and performing drug screenings in F0

Vincenzo Di Donato, Institut Germans Trias i Pujol, Badalona


Effects of eating food containing red meat on inflammation in adult risks: A risk of neurotoxicity for the brain?

Henri Schroeder, Université de Lorraine


6:00-8:00:      Poster Session (see list below)

                       Buffet Dinner


Tuesday, May 23


8:30-10:30:    Neurological Effects of SARS-CoV-2

Chair: Helena Hogberg, National Institute of Environmental Health Sciences


A Systematic Evidence Map of Neurological Effects due to COVID-19

Helena Hogberg, National Institute of Environmental Health Sciences (NIEHS),


The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19

Magda Sachana, Organisation for Economic Co-operation and Development (OECD)


Systems Biology Approaches to COVID-19 Pathogenesis

Daniel Jacobson, Biosciences Division, Oak Ridge National Laboratory


Multiscale Approaches to Elucidate Interactions in Neurological Outcomes of COVID-19

Ann Lam, Physicians Committee for Responsible Medicine


10:30-10:45: Morning Break


10:45-11:45: Pioneer in Neurotoxicology Lecture

Organophosphate insecticides in retrospect:  Lessons learned when a “safe” pesticide isn’t safe

Theodore Slotkin, Duke University


11:45-12:45: Open Platform Talks


Structure-based chemical clustering for developmental neurotoxicity and comparison with MEA datasets from iPSC-neurons

Yasunari Kanda, University of Shizuoka


Application of machine learning to neurotoxicity assessment using human iPS cell-derived neurons

Yuta Suzuki, Yokohama National University


12:45-1:45:    Lunch


2:30-5:30:      Networking Activities

  1. A) Nasher Art Museum
  2. B) Duke Chapel and History of Medicine Library
  3. C) Duke Homestead

All) Sarah Duke Botanical Gardens


6:00-7:00:      Soccer Match at Durham Central Park

7:00-9:00:      Carolina Barbeque Dinner and Bluegrass Music at Durham Central Park


Wednesday, May 24


8:30-11:00:    Linking Endocrine Signaling to Developmental Neurotoxicity (DNT) to Establish Novel Methods for Endocrine Disruption-induced DNT – Results from the ENDpoiNTs Project

Chair: Joëlle Rüegg, Uppsala University


Application of a human in vitro testing battery for endocrine disruptor (ED)-induced developmental neurotoxicity (DNT) to refine EDC hazard assessment

Katharina Koch, Kevin Schlüppmann, Louisa Merit Stark, Saskia Hüsken, Stefan Masjosthusmann, Arif Dönmez, Nils Förster, Ellen Fritsche, Leibniz Research Institute for Environmental Medicine, Ruhr-University Bochum and Heinrich-Heine-University


From Experimental neurobiology to policy making: Unravelling the molecular mechanisms of Endocrine Disruption in the developing human brain

Marco Tullio Rigoli, Cristina Cheroni, Caporale Nicolò, Davide Castaldi, Martina Ciprietti, Sebastiano Trattaro and Giuseppe Testa, European Institute of Oncology, IRCCS, University of Milan and Human Technopole


Sex-specific effects of acute and developmental exposure to bisphenol-A and endosulfan

Lennart V.J. van Melis, Anneloes M. Peerdeman, Eva H.W. Huiberts, Regina G.D.M van Kleef and Remco H.S Westerink, Utrecht University


Cellular and behavioral impacts of EDC on oligodendrogenesis and remyelination

  1. Jubin, C. Guittoneau, E. Martin, M-S. Aigrot, B. Demeneix, JB. Fini, B. Zalc, S. Remaud, Muséum National d’Histoire Naturelle (MNHN) and Sorbonne University


Adverse Outcome Pathways for Endocrine-induced Developmental Neurotoxicity

Diana Lupu and Joëlle Rüegg, Uppsala University


11:00-11:15: Morning Break


11:15-12:15:  Open Platform Talks


The role of brain iron in neurodegenerative diseases

Byron Jones, University of Tennessee Health Science Center


Neuronal genes in wiring and firing: A bottom-up approach for the characterization of gene expression biomarkers for developmental neurotoxicity hazard identification

Bhaja Padhi, Health Canada


12:15-1:15:    Lunch


1:15-3:15:      Acrylamide as a Neurodevelopmental Toxicant – Linking Molecular and Cellular Mechanisms to Human Behavioral Dysfunction

Co-Chairs: Oddvar Myhre, Norwegian Institute of Public Health and Ylva Johansson, Stockholm University



Effects of acrylamide and its metabolite glycidamide in human neural stem cells undergoing differentiation.

Oddvar Myhre, Malene Lislien, Marcin W. Wojewodzic, Nur Duale, Jørn A. Holme, Ragnhild E Paulsen, Inger Margit Alm, Ellen Skarpen, Vigdis Sørensen, Francesca Pistollato and Anna J Lauvås, Norwegian Institute of Public Health (NIPH), Oslo University Hospital, University of Oslo and 4European Commission, Joint Research Centre (JRC)


Neural differentiation pathway disturbances and neurodevelopmental toxicity of acrylamide in the human neural progenitor test (hNPT).

Victoria C. de Leeuw, Conny T.M. van Oostrom, Paul F.K. Wackers, Jeroen L.A. Pennings, Hennie M. Hodemaekers, Aldert H. Piersma and Ellen V.S. Hessel, National Institute for Public Health and the Environment (RIVM)


Acrylamide impairs neuronal differentiation in neuroblast and neural progenitor cell models at concentrations that are relevant for human exposure

Ylva Johansson, Kristina Attoff, Anna Forsby, Stockholm University and Swedish Chemicals Agency (KEMI)


Neurodevelopmental and other developmental effects of acrylamide in birth cohorts

Jan Alexander, Ida Caspersen, Margaretha Haugen, Oddvar Myhre and Kristine Vejrup, Norwegian Institute of Public Health


3:15-3:30:      Afternoon Break


3:30-5:00:      New Insights on the Role of Manganese in Neurodegeneration             

Co-Chairs: Aaron Bowman, Purdue University and Marcia Ratner, Boston University


BTBD9 is regulated by manganese and attenuates manganese-induced oxidative stress and dopaminergic neurotoxicity

Pan Chen, Aaron B Bowman, and Michael Aschner, Albert Einstein College of Medicine and Purdue University


Neurotoxicological outcomes of sub-cytotoxic manganese exposure and neurodegenerative disease risk

Xueqi Tang, Hyunjin Kim, Anke Tukker, Emily Warren, Miles Bryan, Rekha Balachandran, Fiona Harrison, Michael Aschner and Aaron B. Bowman, Purdue University, Vanderbilt University Medical Center, and Albert Einstein College of Medicine


Manganese exposure as a disease modifying risk factor in age at onset of Parkinson’s disease

Marcia Ratner, Boston University School of Medicine


5:00-6:30:      INA Business Meeting and Awards


Dinner on your own


Thursday, May 25


8:30-10:30:    Evaluating new approach methodologies for developmental neurotoxicity: computational models to mechanisms of toxicity                                    

Co-Chairs: Kelly Carstens, US-EPA and Megan Culbreth, PETA Science Consortium International


Comparing the strengths and limitations of concentration-response modeling pipelines for developmental neurotoxicity (DNT) new approach methods (NAMs)

Kelly Carstens, US-EPA


Exploring the influence of experimental design on toxicity outcomes in zebrafish embryo tests

Jui-Hua Hsieh, National Institute of Environmental Health Sciences


Building predictive flame retardants models using the multi-dimensional embryonic zebrafish.

Lisa Truong, University of Oregon


Gaining confidence in the developmental neurotoxicity (DNT) in vitro battery by understanding the mechanism of action of screening data

Ellen Fritsche, Leibniz Research Institute for Environmental Medicine


10:30-10:45: Morning Break


10:45-12:15:  Translational Neurotoxicology from In silico/In vitro/In vivo Models to Lead Compounds in Chemical Threats Research                                                

Chair:  David Jett, National Institute of Neurological Disorders and Stroke


Determination of the Toxicokinetics of TETS and development of neutralizing antibody reagents

Heike Wulff, Brandon Pressly, Natalia Vasylieva, Bogdan Barnych, Vikrant Singh, Pamela J. Lein, Bruce D. Hammock, University of California, Davis  


Efficacy testing and pharmacokinetic analysis of novel brain-penetrating oxime acetylcholinesterase reactivators

Janice E. Chambers, Mississippi State University


Refined uncharged bis-oximes for rapid CNS reactivation of OP-inhibited human acetylcholinesterase.

Andrey Kovalevsky, Thibault Alle, Carlo Ballatore and Zoran Radic, Oak Ridge National Laboratory and University of California San Diego


12:15-12:30: Closing Remarks: Tim Shafer, INA President and Pam Lein, INA President-Elect



92     Scientific Presentations at INA18


2       Keynote Lectures

43     Talks in 11 symposia

3       Trainee talks

7       Open Platform Talks

37     Posters (10 Student, 11 Post-doc, 16 Non-trainee)




Name Title of Presentation Category
1 MaryAnn Hawks Reductions in neocortical parvalbumin expression due to iodine deficiency and ammonium perchlorate exposure Student
2 Alan Kim Synaptogenesis assay for developmental neurotoxicity testing in a human 3D brain model Student
3 Bridget Knapp Identifying negative control chemicals for use in larval zebrafish behavior assays Student
4 Christine Lee Li Mei Embryonic exposure to neonicotinoid insecticide on neuron-glia interaction in the cerebellum of neonatal rat Student
5 Daniel Martinez Translocator Protein 18 kDa (TSPO) and neuroinflammation in the 5XFAD animal model of Alzheimer’s disease Student
6 Katherine Morton High sugar diets modulate oxidative stress induction by 6-OHDA to reduce dopaminergic neurodegeneration in C. elegans Student
7 Sydney Risen Non-toxic nanoligomers targeting key neuroinflammatory pathways are protective in neurodegenerative disease Student
8 Diego Ruiz-Sobremazas Investigating the effects of gestational particulate matter exposure on offspring development and social behavior in rats Student
9 Xueqi Tang IGF/Insulin signaling interruption in acute vs. chronic manganese exposure Student
10 Ryne Thomas Prevalence of periventricular heterotopia following developmental exposure to perchlorate and dietary iodine deficiency in rats Student
11 Gimena Gomez Addressing the impact of PFAS on neurodevelopment using human cortical organoids Postdoc
12 Javier Huayta Neurodegeneration induced by inhibition of mitochondrial complex III in Caenorhabditis elegans Postdoc
13 Dalisa Kendricks Using automated home-cage behavior monitoring systems to characterize sex differences in mice exposed to chlorpyrifos during gestation Postdoc
14 Anna Kreutz Human embryonic stem cell-derived dopaminergic neuron model for neurodevelopmental toxicology screening Postdoc
15 Rebecca Lichtler Prenatal cadmium exposure upregulates re5noic acid signaling and posterior Hoxa and Hoxb paralogs in the developing mouse brain Postdoc
16 Beatriz Molina-Martinez Neurotoxicity profiling in zebrafish larvae using a battery of high content locomotor activity assays Postdoc
17 Andrew Newell Organophophate esters exposure during development dysregulates genes underlying mitochondrial physiology in brain and placenta Postdoc
18 Emily Pitzer Developmental emamectin benzoate exposure alters ontological proteomic signatures in Long Evans rats Postdoc
19 Maren Schenke Implementing sex differences in an in vitro model of the developing human brain Postdoc
20 Jack Thornton Comparative neurotoxicity of traditional and designer benzodiazepines on in vitro spontaneously active rat primary cortical cultures: implications for public health regulation Postdoc
21 Xian Wu Tiered testing of arsenic developmental neurotoxicity using neural organoid and 2D in vitro models Postdoc
22 Gabrielle Bryd Increasing the throughput of a high-content imaging-based developmental neurotoxicity proliferation assay Non-trainee
23 Nathalie Grova Development of an adverse outcome pathway (AOP) to assess the neurotoxicity of the exposure to benzo(a)pyrene Non-trainee
24 G. Jean Harry Consideration of microglia as a target neural cell for assessing neurotoxicity. Why is the smallest always overlooked or misunderstood Non-trainee
25 Bridgett Hill Inconsistencies in variable reporting and methods in larval zebrafish behavioral assays Non-trainee
26 Alex Marshall The influence of arsenic on mechanisms of alcohol-induced neurodegeneration Non-trainee
27 Christopher McPherson Integrating screening level developmental neurotoxicity (DNT) information of chemicals In a new approach methods (NAMs) battery to prioritize compounds for future In-depth study Non-trainee
28 Beatriz Molina-Martinez Neurotoxicity profiling in zebrafish larvae using a battery of high content locomotor activity assays Non-trainee
29 Valentina Schiavone Harmonizing embryonic zebrafish Light/Dark Behavior Test for the OECD Developmental NeuroToxicity In Vitro Battery (OECD DNT IVB) Non-trainee
30 Lena Smirnova Organoid Intelligence (OI). Can we replace learning and memory animal studies with in vitro models? Non-trainee
31 Jacob Smoot Plastic dominates developmental toxicity responses to burn pit-related smoke in zebrafish: Role for polycyclic aromatic hydrocarbons Non-trainee
32 Zhi-Bin Tong 3D-suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons Non-trainee
33 Remco Westerink Micro- and nanoplastics neurotoxicity measured using microelectrode array (MEA) recordings in rat cortical cultures Non-trainee
34 John Wise Using a toxic aging coin for Cr(VI) neurotoxicity: Investigating the intersection of aging and toxicology of hexavalent chromium in the brain Non-trainee
35 Sachiko Yoshida Mutuality between neuronal toxicity and microbiome alteration in acute or chronic exposure to glyphosate Non-trainee
36 Marie-Gabrielle Zurich Are glycol ethers neurotoxic for humans? An in vitro and in silico evaluation Non-trainee
37 Katie Zychowski Neuroinflammatory, sex-dependent consequences and mechanisms following acute woodsmoke exposure Non-trainee